This suggests enough time-title reductions on urinary ratio don’t lower hypertension

This suggests enough time-title reductions on urinary ratio don’t lower hypertension

Despite numerous earlier training revealing a connection ranging from blood pressure level and the brand new urinary Na + /K + ratio there are numerous limits to-be considered

At present there is conflicting evidence regarding the potential blood pressure lowering effects of a reduction in urinary Na + /K + excretion. The TAIM randomized control trial in hypertensive participants on a pharmacological intervention reported no significant difference in DBP between the control diet group and a low Na + /high K + diet group during a six month period . A multicenter study by Suppa et al. conducted in hypertensive participants reported a significant reduction in SBP following 4 weeks of modified low sodium high potassium salt intake compared to participants receiving a normal salt intake , yet all participants were receiving a beta blocker, which is not standard first line treatment for hypertension . In addition, a cross-sectional study, the Dallas heart study, which reported an increase in SBP for an increase in the urinary Na + /K + ratio is limited by the modest correlation the use of single morning urine sample . The PURE study reported a strong linear association between estimated Na + /K + ratio and SBP, that was maintained after covariate adjustment, with the greatest SBP observed with the highest estimated K + and lowest estimated K + excretion . Although we observed that a daily K + excretion of <1 g/day is associated with elevated SBP we observed no association between the urinary Na + /K + excretion ratio and SBP at screening or following DASH-dietary intervention in SS or SR participants. In conjunction with the study by Zanetti et al. , our data suggest high Na + and low K + excretion may increase the likelihood of having increased SBP. However, the lack of association between urinary Na + /K + ratio and SBP in our data do not support a urinary Na + /K + molar excretion ratio of 1:1 as a mechanism to lower blood pressure [16, 17].

The present day analysis has several strengths: (1) This new Dash -Sodium demonstration is a thoroughly managed feeding investigation and you will compliance try consistently monitored, (2) The new crossover structure to own Na + input enjoy participant’s in order to serve as her manage and you will decreased inter-individual variability, (3) 24-h ambulatory blood pressure level tracks have been removed, (4) lack of the new confounding negative effects of antihypertensive mediations, and you may (5) 24-h urine test range. The top maximum of expose research is the seemingly more compact shot dimensions that keeps diminished the mathematical capacity to select smaller aftereffects of urinary Na + , K + , and Na + :K + ratio into the SBP. While we failed to to see an instability during the baseline features, residual confounding within our data can be done.

Subsequent, the brand new INTERSALT data, hence noted an optimistic association amongst the urinary Na + /K + ratio and you will blood circulation pressure reported a loss in mathematical dependence on the fresh correlation in 49 of 52 stores just after changes to have covariates and decades, sex and you can Body mass index [thirty-two, 33]

In conclusion the modern research of your Dash–Salt Trial indicates that weight loss K + supplements is not for the all the way down SBP hence the decreases in SBP noticed adopting the Dashboard weightloss intervention taken place independently out of a beneficial reduction of new urinary Na + /K + removal ratio regardless of the new sodium awareness out-of blood pressure level. All of our analysis do not hold the business of a-1:1 molar excretion ratio of Na + /K + because the hypertension minimizing means in the Us African american and you can non-African Us citizens and you can hold the DRI recommendation to not recommend every day K + consumption advice. Because of the limitations of your latest research and also the lingering debate concerning your character from weightloss K + to the blood circulation pressure coming carefully managed scientific studies are necessary to elucidate the possibility perception from fat reduction K + and you may urinary Na + /K + excretion proportion into the blood pressure in hypertensive and you may normotensive SS and you will SR users.

Tags: No tags

Add a Comment

Your email address will not be published. Required fields are marked *